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As we mentioned earlier in the week, some Black Friday sales have already begun. (It gets earlier and earlier every year, right?) While some are nothing to write home about, the deals at Target have us all sorts of excited — especially the two-day sale happening this Saturday and Sunday.

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Trader Joe’s is a lot of people’s favorite supermarket. Its specialty items — like cookie butter and cultured, salted French butter (the best thing that ever happened to toast) — are beloved. But Trader Joe’s is more than just a place to buy quirky snacks. It’s also a great place to stock up on inexpensive staples for everyday dinners and holidays alike.

To see how Trader Joe’s stacks up to other stores, I went to one in Chicago on a Saturday afternoon and priced out all the ingredients necessary to make a complete Thanksgiving dinner.

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Great British Bake Off fans, if I’m breaking this news to you I apologize and commend you on your solid internet consumption boundaries. But scrummy Mary Berry and dirty punsters Mel and Sue are not in the newest season, which has been airing in Britain over the past couple months on Channel 4.

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Really, this could easily be a side dish as well as a dip. It’s a simple preparation of twice-baked butternut squash — roasted until it’s buttery soft and scoopable, then blended with milk and plenty of nutty Parmesan and baked with a cheesy crust on top.

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There are many compelling reasons to decide to volunteer at a soup kitchen, but the bottom line is simple and sincere: You want to help. But what does it mean to be helpful in these circumstance? Sometimes that’s a complicated question with an equally complicated set of answers.

Here are six things to keep in mind when volunteering at a soup kitchen.

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Inline_The Insulin-Illness ConnectionMost discussion of chronically-elevated insulin levels (hyperinsulinemia) and insulin resistance revolves around their relationship to bodyweight. This is unsurprising. Bodyweight’s what “sells tickets.” It’s why most people get interested in diet, health, fitness, and nutrition—to lose weight or avoid gaining it.

But improving insulin sensitivity and reducing fasting insulin levels have major ramifications for your health, longevity, and resistance to disease. And it’s not just because “weight gain is unhealthy.” Insulin itself, in excess, exerts seriously damaging effects. Today, I want to impress upon you the importance of controlling your insulin response by laying out some of the health problems that stem from not controlling it.

Hyperglycemia

If you’re insulin resistant, insulin doesn’t work very well. You need more of it to get the same effect an insulin sensitive person would get. When insulin doesn’t work, its ability to shuttle glucose out of the blood suffers, and blood glucose goes up and stays up. That’s hyperglycemia. Everyone “knows” that high blood sugar is bad, but why? What exactly goes wrong?

Some cells are passive recipients of blood sugar, while others have mechanisms that prevent excess blood sugar from entering their membranes. In the presence of high blood sugar, the passive recipients begin producing excessive amounts of reactive oxygen species (ROS). ROS aren’t pathological in and of themselves. They’re signaling molecules that our bodies need for healthy cellular function. But unchecked ROS generation induced by hyperglycemia causes a lot of problems.

In endothelial cells, hyperglycemia inhibits the production of nitric oxide. Nitric oxide is a vasodilator—it helps our blood vessels widen to accommodate increased blood flow and reduce shear stress. Without sufficient nitric oxide, our blood vessels are more susceptible to high blood pressure and our risk for heart disease and atherosclerosis goes up.

In neurons, hyperglycemia causes shrinkage. No one likes shrinkage, especially not in the brain cells where thinking occurs.

In pancreatic beta cells, hyperglycemia reduces cell mass, induces oxidative stress, and reduces functionality. Since the pancreas secretes insulin—the stuff used to deal with excess blood glucose—this is disastrous.

Cancer

Insulin is a growth promoting agent, and cancer is a disease of unchecked cellular growth. There are nuances to this of course. But by and large, those are true statements. It’s no surprise that hyperinsulinemia is a risk factor for most, if not all cancers.

While insulin isn’t everything when it comes to cancer, the links are undeniable and myriad—and worrying.

The link between colon cancer and hyperinsulinemia likely involves the increased availability of insulin-like growth factor in a hyperinsulinemic state. Post-menopausal women with genetic variants related to insulin resistance and hyperinsulinemia have a greater risk of colorectal cancer, and colon cancer patients who eat the most insulinogenic foods have poorer outcomes.

In breast cancer, hyperglycemia increases the tumors’ resistance to chemotherapy. Fixing the hyperglycemia makes chemotherapy more effective.

People with a genetic predisposition toward hyperinsulinemia have a higher chance of developing pancreatic cancer.

Independent of bodyweight, hyperinsulinemia predicts endometrial cancer; so does a high postprandial insulin response.

Diabetics who use insulin therapy have an increased risk of liver cancer.  One study of Taiwanese diabetics found that those on insulin therapy have an elevated risk of dying from cancer and from non-cancer.

Across the board, in both obese and people of normal bodyweight, hyperinsulinemia, whether it’s genetic, simulated, or diet-driven, increases cancer incidence and mortality. 

Okay, okay. That’s all rather convincing, but there’s a chance that these are merely associations and some common factor is causing both the hyperinsulinemia/insulin resistance and the cancer. Right?

What seems to counter that hypothesis is the effect of metformin, an anti-diabetic drug, on cancer. Compared to other diabetic drugs, metformin reduces the risk of cancer in type 2 diabeticsMetformin’s mechanism of action? A reduction in insulin levels and improvement of insulin resistance. 

Alzheimer’s Disease

Alzheimer’s hits families like a freight train, but if you know what to look for you can see it coming.

Alzheimer’s and other forms of dementia are characterized by brain insulin resistance. In experiments where researchers simulate brain diabetes by administering drugs known to induce brain insulin resistance, it looks almost exactly like Alzheimer’s. Some people even call Alzheimer’s type 3 diabetes, so closely is it linked to insulin resistance. 

Alzheimer’s patients have high blood sugar, but their neurons are so resistant to the effects of insulin that they’re unable to utilize the available glucose for energy. That’s why ketogenic diets and ketones in particular are so helpful for Alzheimer’s; they offer an alternative fuel source that even the insulin resistant brain can utilize.

Heart Disease

Independent of most other factors, insulin resistance predicts heart disease riskOne of the best predictors of heart disease risk—the HDL:triglyceride ratio—also happens to be an accurate barometer of insulin resistance. The lower your HDL and the higher your triglycerides, the more likely you are to be insulin resistant. 

The two go hand in hand, and it’s not just a coincidence.

As you saw in the hyperglycemia section, insulin resistance can increase the risk of heart disease by increasing hyperglycemia and reducing endothelial function. This impairs the blood vessels’ ability to react to stressors and makes them more vulnerable to atherosclerosis.

What You Can Do

A big step, maybe the first step when you’re insulin resistant with hyperinsulinemia, or even just suspect you are, is to reduce your intake of the most insulinogenic macronutrient around: carbs. This stems the tide and stops feeding the fire until you can figure out and resolve the root cause of your dysfunction.  

That next part is harder. Some of it is genetic; there will be people who simply make more insulin than others, or who are more insulin resistant as a baseline. Oftentimes the dysfunction is multifactorial, stemming from a dozen different causes, all of which require your attention. In past posts, I’ve explained strategies for combating insulin resistance and reducing hyperinsulinemia. If you haven’t read those yet, do so.

Take the issue seriously, whatever you do. An expanding waistline might be unsightly and undesirable, but it usually doesn’t strike fear into hearts and minds. You know what does, and what should?

  • Developing a cancer you didn’t have to develop and dying earlier than you should have.
  • Seeing your sanity and identity slip away as your helpless family members watch in vain.
  • Bathing your neurons and arteries in a toxic hyperglycemic soup until they wither and atrophy.

Take care of your insulin response, folks. It’s fundamental.

Thanks for reading, everyone. Take care, be well, and let me know what you think about all this down below!

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Thanksgiving with extended family comes with its own set of rules, and they’re usually as unique and particular as the families themselves. Friendsgiving, however, is an entirely different story. That’s because Friendsgiving is, at its heart, a potluck, not a longstanding family tradition. And like any good potluck, there are rules for engagement to ensure it comes off without a hitch.

If you’re hosting Friendsgiving this year, we commend you. It’s a big undertaking with lots of planning involved. If you’re nervous or a little in over your head, remember these 10 rules and you’ll be fine.

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Whole Foods is shockingly not that expensive when it comes to shopping for ingredients for a Thanksgiving menu. (We know because we priced it out!) But even if you plan on shopping somewhere else for the holiday, you might still want to swing by the big chain for a few odds and ends.

Related: I Went Shopping for Thanksgiving at Whole Foods & This Is How Much It Cost

Whole Foods stocks beautiful products and a few little things to make a Thanksgiving dinner really special. Whether you’re cooking a banquet at home or making a contribution to your Friendsgiving potluck, here are three things to buy at Whole Foods for Thanksgiving.

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It’s hard to imagine, but we’re less than two months away from 2018. That means it’s time to start wrapping up 2017 and thinking about the new year. This week Whole Foods released their annual forecast of the flavors, products, and culinary influences that will take off in the next year.

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When you don’t have a ton of time to dedicate to cooking a main dish and sides for dinner, a one-pan meal is the perfect solution. In this case, chicken thighs, fresh veggies, and rice cook all together in a pan with a flavorful coconut curry sauce. In about 40 minutes you’ll have your protein, starch, and veggies — and only one pan to wash after dinner. It doesn’t get any better than that!

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