Genetics & Obesity – Prader-Willi Syndrome

December 23, 2009

A few days ago, I met a woman whose young child has been diagnosed with Prader-Willi Syndrome.
And while I am no expert on Prader-Willi, I have a general idea of the associated symptoms.
These include:

low levels of testosterone
sleep disorders
strabismus (mis-aligned eyes)
scoliosis
delayed puberty
weak muscles
extreme flexibility
learning disabilities
various

and an insatiable desire to eat which leads to compulsive overeating, morbid obesity and an increased risk of diabetes and various other obesity related conditions

The cause of PWS is genetic.
Although the exact genes responsible for Prader-Willi syndrome haven’t been identified, the problem is known to lie in a particular region of chromosome 15.
This defect in chromosome 15 leads to a malfunctioning hypothalamus.

This results in a flaw in the hypothalamus part of their brain, which normally registers feelings of hunger and satiety. The number of oxytocin neurones–the putative satiety neurones–in the hypothalamic paraventricular nucleus is markedly decreased in Prader-Willi syndrome. This is presumed to be the basis of […]

Original post by healthhabits

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