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Accumulation of a toxic class of fat metabolites, known as ceramides, may make people more prone to type 2 diabetes.

It’s just as possible for a thin person to have diabetes as it is for many obese people to be surprisingly healthy.

 

Among patients receiving gastric bypass surgery in Singapore, ceramide levels – waxy lipid molecules found in cell membranes – predicted who had diabetes better than obesity did. Although all of the patients were obese, those who did not have type 2 diabetes showed less ceramide in their adipose tissue than those who were diagnosed with the condition.

 

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